만성 증식성 캔디다증에서 hBD-2의 발현과 T 림프구 침윤에 관한 연구
Expression of hBD-2 and Infiltration of T Lymphocytes in Chronic Hyperplastic Candidiasis
윤대웅, 조영아, 김수진, 윤혜정, 홍성두, 이재일, 홍삼표,
소속 상세정보
윤대웅 ( Yoon Dae-Woong ) - 서울대학교 치의학대학원 구강병리학교실
조영아 ( Cho Yeong-Ah ) - 서울대학교 치의학대학원 구강병리학교실
김수진 ( Kim Soo-Jin ) - 서울대학교 치의학대학원 구강병리학교실
윤혜정 ( Yoon Hye-Jung ) - 서울대학교 치의학대학원 구강병리학교실
홍성두 ( Hong Seong-Doo ) - 서울대학교 치의학대학원 구강병리학교실
이재일 ( Lee Jae-Il ) - 서울대학교 치의학대학원 구강병리학교실
홍삼표 ( Hong Sam-Pyo ) - 서울대학교 치의학대학원 구강병리학교실
KMID : 0829220120360030171
Abstract
Chronic hyperplastic candidiasis (CHC) is characterized by epithelial hyperplasia of the oral mucosa associated with candidal hyphae. The immune status of host is one of the factors that induce clinically evident candidal infection. Host defense mechanisms include inflammatory cells, epithelial barrier, and antimicrobial peptides such as human beta 2 defensin (hBD-2). In the present study, we investigated the densities of CD4+/CD8+ T lymphocytes and hBD-2 expression of epithelial cells in CHC. Immunohistochemical staining was performed on 10 cases of CHC using CD4, CD8 and hBD-2. Ten specimens of chronic mucositis were selected for comparison, and went through the same examination. hBD-2 was expressed in the spinous cell layers and the keratin layers of 7 CHC patients, while the epithelium of chronic mucositis did not demonstrate the hBD-2 expression except for one case. Also, hBD-2 expression was stronger when the hyphae invaded the upper stratum spinosum (P =.019). However, the densities of CD8+ T lymphocytes were significantly lower in the CHC patients, suggesting that the ability of CD8+ T cells to enter the epithelium and target the pathogenic hyphae was decreased in CHC. Increased hBD-2 expression seemed to be significantly associated with the candidal infection, while not promoting the cell-mediated immune reaction in CHC.
키워드
Chronic Hyperplastic Candidiasis;Human beta 2 Defensin;T Lymphocyte
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